No, that's a bad idea. There's no hurdle or legal issue, and money isn't behind it either. Those "prefixes" (area codes) are all the same segments of this or that national numbering plan that are also allocated by legitimate businesses both for placing legitimate outbound calls to their customers and for numbers that connect e.g. switchboards/IVRs to serve customers who are calling in.
If a specific region (or more likely: operators within it) are responsible for the vast majority of abusive traffic, then absolutely they should bear the consequences of this. Yes, there's collateral damage, but those negatively affected by being unable to make legitimate calls should be a prime lobby for effective egress control from their respective operators and regulators.
The ones to really bear the consequences are legitimate businesses and the customers of these businesses. It sounds like your desire to see offenders punished, instead of the problem actually being solved with the help of functional regulations, makes you incapable of seeing the wider picture.
